1. Life: Chemical, Cellular, and Evolutionary Foundations

Case 1 The First Cell: Life’s Origins

2. The Molecules of Life

New coverage of functional groups

3. Nucleic Acids and Transcription

Nucleotides now shown at physiological pH

4. Translation and Protein Structure

Amino acids now shown at physiological pH

5. Organizing Principles: Lipids, Membranes, and Cell Compartments

6. Making Life Work: Capturing and Using Energy

7. Cellular Respiration: Harvesting Energy from Carbohydrates and Other Fuel Molecules

8. Photosynthesis: Using Sunlight to Build Carbohydrates

The story of the evolution of photosynthesis now brought together in a single major section at the end of the chapter (Section 8.5).

Case 2: Cancer: When Good Cells Go Bad

9. Cell Signaling

10. Cell and Tissue Architecture: Cytoskeleton, Cell Junctions, and Extracellular Matrix

Chapters 9 and 10 have been streamlined to better match our mission statement.

11. Cell Division: Variations, Regulation, and Cancer

Case 3 You, From A to T: Your Personal Genome

12. DNA Replication and Manipulation

New inclusion of the trombone model of DNA replication

Addition of CRISPR technology

13. Genomes

Expanded coverage of retrotransposons and reverse transcriptase

14. Mutation and DNA Repair

15. Genetic Variation

16. Mendelian Inheritance

A new How Do We Know? figure explaining Mendel’s experimental results

17. Inheritance of Sex Chromosomes, Linked Genes, and Organelles

18. The Genetic and Environmental Basis of Complex Traits

19. Genetic and Epigenetic Regulation

New discussion of the mechanism of X-inactivation

20. Genes and Development

Case 4 Malaria: Coevolution of Humans and a Parasite

21. Evolution: How Genotypes and Phenotypes Change Over Time

An expanded discussion of nonrandom mating and inbreeding depression

22. Species and Speciation

23. Evolutionary Patterns: Phylogeny and Fossils

Addition of the effect of mass extinctions on species diversity

24. Human Origins and Evolution

Updated discussion of the relationship between Neanderthals and Homo sapiens, as well as Denisovans

25. Cycling Carbon

Significantly revised link between the carbon cycle, biodiversity, and ecology

Case 5 The Human Microbiome: Diversity Within

26. Bacteria and Archaea

27. Eukaryotic Cells: Origins and Diversity

New branching order of the eukaryote tree in this chapter and onward to reflect new research in the past three years

28. Being Multicellular

Case 6 Agriculture: Feeding a Growing Population

29. Plant Structure and Function: Moving Photosynthesis onto Land

A new discussion of plant nutrients

30. Plant Reproduction: Finding Mates and Dispersing Young

An enhanced discussion of seeds, including the development of the embryo and dispersal structures

New coverage of the genetic advantages of alternation of generations

Addition of apomixis

31. Plant Growth and Development

The section on the role of plant sensory systems in the timing of plant reproduction has been moved from Chapter 30 to Chapter 31.

32. Plant Defense: Keeping the World Green

33. Plant Diversity

Completely revised explanation of the basis for angiosperm diversity

Plant and animal diversity chapters (Chapters 33 and 44) now include a brief review of organismal form and function, allowing these chapters to be used on their own or before the physiology chapters.

34. Fungi: Structure, Function, and Diversity

Case 7 Predator-Prey: A Game of Life and Death

Brief descriptions of unfamiliar organisms and the major groups of organisms have been layered into the animal physiology chapters, to make it easier to teach physiology before diversity (Chapters 35-42).

35. Animal Nervous Systems

36. Animal Sensory Systems and Brain Function

37. Animal Movement: Muscles and Skeletons

38. Animal Endocrine Systems

39. Animal Cardiovascular and Respiratory Systems

A new section on the composition of blood

40. Animal Metabolism, Nutrition, and Digestion

41. Animal Renal Systems: Water and Waste

42. Animal Reproduction and Development

New diagrams of hormone feedback loops in the menstrual cycle

43. Animal Immune Systems

A new introduction to the immune system

Case 8 Biodiversity Hotspots: Rain Forests and Coral Reefs

44. Animal Diversity

A new discussion of nematodes

Introduction of a newly-discovered species, Dendrogramma enigmatica

45. Animal Behavior

46. Population Ecology

A new population growth equation

47. Species Interactions, Communities, and Ecosystems

A new discussion of facilitation

An expanded discussion of herbivory

A new example of microbial symbionts

A new discussion of biodiversity and its importance

48. Biomes and Global Ecology

An entirely new chapter on physical processes that underlie different biomes

• Differential solar energy around the globe and seasonality
• Wind and ocean currents
• Effects of circulation and topography on rainfall
• Expanded discussion of terrestrial biomes
• Freshwater and marine biomes
• Integration of concepts of biogeochemical cycles from Chapters 25 and 26 with ecological concepts
• Global patterns of primary production
• Global biodiversity

49. The Anthropocene: Humans as a Planetary Force

A new Core Concept and discussion of conservation biology